As i have already told you that there is a lot of loss of blood in the nephritic syndrome while in nephrotic syndrome, there is loss of proteins and this is the most basic difference between the two. Nephrotic syndrome massive proteinuria 1gm 2day spot prot. Lower excess salt and fluids in the body lower loss of protein in the urine lower cholesterol in the blood certain medicines that suppress or calm the immune system can be used. The finnish type is an autosomal recessive disorder most common presents during the. Discuss the management of a 6yr old with recurrent urinary tract infection. Nephrotic syndrome see figure 1 is usually a chronic condition and with the exception of mcd, most causes eventually lead to chronic progressive renal failure.
Edema may also be present, although it is not nearly as severe as in nephrotic syndrome. Laboratory findings include hematuria, proteinuria nephrotic syndrome adam goldstein howard trachtman, m. Nephrotic or nephritic syndrome can be caused by multiple disease processes. It often occurs in the glomerulus, where it is called glomerulonephritis. Lower excess salt and fluids in the body lower loss of protein in the urinelower cholesterol in the blood certain medicines that suppress or calm the immune system can be used. Difference between nephrotic syndrome and nephritic syndrome. Specifically, its a type of nephrotic syndrome, in fact, the most common nephrotic syndrome seen in children. Genetic studies in children with familial nephrotic syndrome have identified mutations in genes that encode important podocyte proteins. Pediatric nephrotic syndrome national kidney foundation. Pages with both nephrotic and syndrome in the title are. Nephrotic syndrome is also associated with clinically important complications related to urinary loss of proteins other than albumin. Recent advances in understanding and treating nephrotic. Understand the various factors that affect the prognosis of nephrotic syndrome. Efforts to minimize treatment toxicity showed that prolonged treatment after an initial treatment for 23 months with glucocorticosteroids was not effective in reducing frequent relapses.
What is the initial step in the pathophysiology of nephritic syndromes. Nephrotic syndrome presents clinically with massive proteinuria and hypoalbuminemia, accompanied by variable forms of edema, hyperlipidemia, and lipiduria, all as a result of increased glomerular permeability 1, and it can be associated with nephritic syndrome when some or all of its clinical concomitant manifestations arterial hypertension, hematuria, hypocomplementemia and. Jul 15, 2018 in this article, we will be sharing a mnemonic for nephrotic syndrome features. Definition nephrotic syndrome is a primary glomerular disease characterized by proteinuria, hypoproteinemic edema and hypercholesterolemia hypoalbuminemia, hyperlipidemia. However, there are differences between nephrotic syndrome and nephritic syndrome in the clinical features. Pharaoh is the mnemonic to remember the nephrotic syndrome syndrome. First deciding between nephritic and nephrotic syndrome is a useful starting point for your differential diagnosis. Diagnosis and management charles kodner, md, university of louisville school of medicine, louisville, kentucky i n nephrotic syndrome, a variety of disorders cause. As a result of hypoalbuminaemia, nephrotic syndrome.
What is the difference between nephritic and nephrotic. Regardless of origin, the basic condition is characterized by hematuria, mild non nephrotic, ie less than 3. Glomerulonephritis is a term given to those diseases that present in the nephritic spectrum and usually. Nephritic spectrum glomerular diseases current medical. Because the differential diagnosis for glomerulonephritis gn is broad, using a classification schema. Nonetheless, age should not be the only factor in defining the etiology of nephritic. Aug 21, 2015 while the incidence of nephrotic syndrome ns is decreasing in korea, the morbidity of difficulttotreat ns is significant.
Nephritic syndrome is a syndrome comprising signs of nephritis, which is kidney disease involving inflammation. Download fulltext pdf 1207 treatment and diagnosis of the nephritic syndrome in children article pdf available in archives of disease in childhood. Nephrotic syndrome is a clinicopathological condition which develops when there is significant damage to the glomeruli which leads to heavy proteinuria 3. Nephritic syndrome is characterized by glomerular damage leading to hematuria, pyuria, water retention, and subsequent hypertension and edema. Laboratory findings include hematuria, proteinuria nephritic syndrome include postinfectious glomerulonephritis, iga nephropathy berger disease, thin basement membrane disease, and rapidly progressive glomerulonephritis. In addition to the massive proteinuria, hypoalbuminemia with plasma albumin levels less than 3gdl, generalized edema, hyperlipidemia and lipiduria also can be observed. Nephrotic syndrome is a collection of symptoms due to kidney damage. Nephrotic syndrome poc nephritic syndrome edema hypoalbuminemia proteinuria hypercholesterolemia not essential characteristic htn mild edema oliguria azotemia high jvp dark urine any inflammation cause proteinuria then edema then hypovolemia then more hypoalbuminemia and hyperlipidemia mechanism 2 immunological disorder causing thickening. Nephrotic syndrome is a condition involving the loss of significant volumes of protein via the kidneys proteinuria which results in hypoalbuminaemia. It can occur in any kidney disease where damage to the filtering units causes protein to leak into your urine. Jul 19, 2017 nephrotic range proteinuria is the presence of 3 g or more per day of protein in the urine or the presence of 2 g of protein per gram of urine creatinine on a single spot urine collection. Pathophysiology you have a charge barrier and a size barrier.
Pediatric nephrotic syndrome adam goldstein howard trachtman, m. Nephrotic syndrome ns reflects glomerular dysfunction. Many of the diseases are characterised by inflammation either of the glomeruli or of the small blood vessels in the kidneys, hence the name, but not all diseases necessarily have an inflammatory component as it is not strictly a single disease, its presentation depends on the. The nephrotic syndrome leakage of 3 grams of protein per day. Minimalchange disease, sometimes called nil disease, affects the millions of the kidneys glomeruli, which are the specific parts of the kidney where small molecules are first filtered out of blood and into the urine.
The term nephrotic syndrome refers to a distinct constellation of clinical and laboratory features of renal disease. Hodgkin disease, usually none nephrotic syndrome bun in 15 30% hla b8, b12 3. Gpnotebook stores small data files on your computer called cookies so that we can recognise you and provide you with the. An external file that holds a picture, illustration, etc. Nephrotic syndrome ns consists of peripheral edema, heavy proteinuria, and hypoalbuminemia, often with hyper lipidemia. Normally nothing larger than 70kd and nothing polyanionic can get through. Children who have evidence of glomerular bleeding may have nephritic syndrome secondary to glomerulonephritis, and those with heavy proteinuria are likely to have nephrotic syndrome. Nephritic syndrome is defined by hematuria, variable degrees of proteinuria, usually dysmorphic red blood cells rbcs, and often rbc casts on microscopic examination of urinary sediment.
Nephrotic syndrome develops when there is damage to the glomeruli, the structures in the kidneys that work to filter the blood. In this article, we will be sharing a mnemonic for nephrotic syndrome features. In a nephrotic syndrome, a group of manifestations occur, such as protein in the urine, edema, low count of albumin in the blood, and lastly too much lipids or fats circulating in the blood. With gbm damage, both of these barriers can be disrupted.
Nephritic syndrome can present with oliguria, hypertension, and hematuria colacolored urine. Nephrotic syndrome with a nephritic component associated with. The nephrotic syndrome is defined by a urinary protein level exceeding 3. Nephritic syndrome is a clinical syndrome defined by the association of hematuria, proteinuria, and often arterial hypertension and renal failure. Nephrotic vs nephritic syndrome linkedin slideshare. Patients with idiopathic nephrotic syndrome are initially. Scribd is the worlds largest social reading and publishing site. Nephrotic syndrome versus nephritic syndrome current. Difference between glomerulonephritis and nephrotic. Fever, rash, arthralgia, and eosinophilia with a bland urinalysis minimal cellular elements in the presence of akf are typical of acute interstitial nephritis. Other symptoms may include weight gain, feeling tired, and foamy urine. In some cases, nephrotic syndrome can lead to kidney failure, which is treated with dialysis or a kidney transplant. It is specifically defined by the presence of heavy proteinuria protein.
Sometimes, the dose might need to be changed, or a different medicine might be used. Nephrotic syndrome is not a specific kidney disease. Theyll give your presentations a professional, memorable appearance the kind of sophisticated look that. Your child may be able to go home from the hospital the same day but this might not be possible if.
Difference between nephrotic and nephritic syndrome compare. Causes of nephritic syndrome include postinfectious glomerulonephritis, iga nephropathy berger disease, thin basement membrane disease, and rapidly progressive glomerulonephritis. Winner of the standing ovation award for best powerpoint templates from presentations magazine. One of the defining features used to determine the difference between nephritic and nephrotic syndromes is the amount of protein in the urine. Learn vocabulary, terms, and more with flashcards, games, and other study tools. Nephrotic and nephritic syndrome renal pathology by dr. Definition nephrotic syndrome is a clinical complex characterized by a number of renal and extrarenal features, most prominent of which are proteinuria in practice 3. Common causes of nephrotic syndrome are listed in table 3.
This damage allows proteins in the blood such as albumin to leak into the urine, causing increased excretion of protein proteinuria see patient education. Ppt acute nephritic syndrome powerpoint presentation. Difference between nephrotic syndrome and nephritic. Glomerulonephritis is characterized by inflammation and thinning of the glomerular basement membrane and the occurrence of small pores in the podocytes of the. Studies suggest that the pathogenesis of edema in individual patients may occur via widely variable. Just like nephritic syndrome, this one also has following features. Overview of nephritic syndrome genitourinary disorders. Basic information nephrotic syndrome ns reflects glomerular dysfunction causing proteinuria without compromising gfr occurs at all ages but is most prevalent in children between the ages 1. Worlds best powerpoint templates crystalgraphics offers more powerpoint templates than anyone else in the world, with over 4 million to choose from. Recognize complications associated with nephrotic syndrome, including those resulting from diuretic therapy. The definition of nephrotic syndrome includes both massive proteinuria. Key difference glomerulonephritis vs nephrotic syndrome a syndrome is a combination of medical problems that show the existence of a particular disease or mental condition. Nephrotic syndrome may appear as a primary idiopathic renal disease or occur in association with any of a number of systemic conditions and hereditary diseases.
It can be caused nephritic syndrome knowledge for medical students and physicians. It can be caused by a variety of conditions including autoimmune, hereditary, and infectious diseases. Diagnosis and manage ment of nephrotic syndrome in adults. In a nephritic syndrome, all of these occur plus there. This learning card provides an overview of nephritic syndrome. Pdf nephrotic syndrome is an important presentation of glomerular disease characterised by heavy. The underlying abnormality in nephrotic syndrome is an permeability of the glomerular capillary wall proteinuria and hypoalbuminemia. Nephrotic and nephritic syndromes are common childhood conditions presenting with oedema and proteinuria. Nephrotic the nephrotic sediment is associated with heavy proteinuria and lipiduria, but few cells or casts and is typically considered bland.
Nephritic syndrome features mnemonics medicos ideas. Most minimal change diseases do respond to corticosteroids and a small fraction of patients are steroid dependent. Complications may include blood clots, infections, and high blood pressure. Pediatric nephrotic syndrome differential diagnoses. Idiopathic nephrotic syndrome nephrotic syndrome without known etiology heavy proteinuria 3. Protein in the urine proteinuria beyond the basics. Nephrotic syndrome what you should know depending on the disease and persons overall health, dietary changes and medicines are used to. Nephritic definition of nephritic by the free dictionary. Treatment includes nonspecific measure aimed at controlling hypertension, edema. This includes protein in the urine, low blood albumin levels, high blood lipids, and significant swelling. Difference between nephrotic and nephritic syndrome.
Nephritic syndrome subendothelial ics with granular if type 1. Early diagnosis is especially important in patients with fulminant disease, where delay in treatment greatly reduces the likelihood of a beneficial. Nephrotic syndrome poc nephritic syndrome edema hypoalbuminemia proteinuria hypercholesterolemia not essential characteristic htn mild edema oliguria azotemia high jvp dark urine any inflammation cause proteinuria then edema then hypovolemia then more hypoalbuminemia and hyperlipidemia mechanism 2. Nephritic syndrome knowledge for medical students and. Nephritic syndrome is a clinical syndrome defined by. Nov 07, 20 nephrotic and nephritic syndromes are common childhood conditions presenting with oedema and proteinuria. The most common primary glomerular diseases include membranous nephropathy, focal segmental glomerular sclerosis, minimal change, and membranoproliferative glomerulonephritis mpgn. Patrick niaudet, in comprehensive pediatric nephrology, 2008. Difference between glomerulonephritis and nephrotic syndrome. Nephrotic syndrome investigations quantify how severe nephrotic syndrome.
Below is just a quick overview of which diseases are associated with which. This is because each is associated with a particular subset of diseases. Nephrotic syndrome is the combination of nephrotic range proteinuria with a low serum albumin level and edema. Glomerulonephritis gn is a term used to refer to several kidney diseases usually affecting both kidneys.
Results the indications for biopsy were nephrotic syndrome ns in 36. Patients typically present with edema and fatigue, without evidence of. Nephrotic syndrome 75% 15% manifestations 26, some adults 2. Diagnosis and manage ment of nephrotic syndrome in. Genetic studies in children with familial nephrotic syndrome have identified mutations in. Acute kidney failure akf is a rare complication of idiopathic nephrotic syndrome. Age plays an important role in identifying the cause of nephritic syndrome. This article will talk about nephritic syndrome and nephrotic syndrome and the differences between them in detail highlighting their. Patients with nephrotic syndrome mahidol university. Nephritic syndrome an overview sciencedirect topics. At the turn of the century, clinicians distinguished a nephritic syndrome. Certain medicines that suppress or calm the immune system can be used. Nephrotic syndrome is a disorder of the kidneys that results from increased. Identify the cause of hyponatremia in nephrotic syndrome.